We read the ingredients, the published research and the refund small print for 54 supplements, then tell you plainly what we found. No star ratings, no scores.
Every review checks the full formula against the official label, reads any published trial in full (including who paid for it), and spells out what the refund really covers and when it runs out.
Trusted Health Reviews is a supplement review site, and the brands it covers pay it commissions. We started from one belief: readers should get straight, research-based information on the supplements they're weighing, including where the evidence is thin.
Our editorial team starts every review with the product's label and official pages, then reads the guarantee terms. We also search for published research on the product and on its ingredients, noting who paid for it and whether the doses line up.
Here is how the money works. When readers buy through our links, we earn affiliate commissions, which manufacturers pay and which fund our research. As far as we know, our link costs the same as going to the site directly. Because the brands we review pay us, we work to describe each product accurately. Every brand we cover is one we have an affiliate relationship with, so our top picks are the best within what we cover, not the best across the whole market.
Every product gets the same checks, whether it's VigRX Plus (on sale since about 2007) or a newer longevity supplement like GenuinePurity NMN-H. We skip numeric scores. Each product gets a plain “best for” label, and each category gets a top pick.
Please note: Dietary supplements make up most of what we review, alongside a few cosmetics, an OTC drug (a benzocaine spray), a fragrance and a device. No product here is a prescription medicine. Supplements are not intended to diagnose, treat, cure or prevent any disease. Talk to a qualified healthcare professional before starting any supplement program. *These statements have not been evaluated by the Food and Drug Administration.
The brands we review pay us commissions, so we show you what we check, cite our sources and say where the evidence is thin. Each product goes through the same six checks before we write a verdict. Our own lab tests and clinical trials aren't part of this; we read what has been published and explain it in plain terms.
We publish no numeric scores. Each product has a “best for” label, and each category has a top pick. Every brand we cover is one we have an affiliate relationship with, so our top picks are the best of the products we cover, not of every product on the market. Formulas, prices and guarantee terms are rechecked whenever we update a review, and the current facts were checked in October 2026.
The label and official product pages tell us exactly what's in each product and how much. Any dose that isn't disclosed gets flagged.
We search for published trials of the product and of its main ingredients. Then we set the doses that were studied beside the doses in the formula, and record who paid for each study.
On the maker's site we read the money-back terms: the deadline, whether opened bottles count, who pays shipping, and any subscription traps.
For the main ingredients we list known side effects and medicine interactions, and say who should check with a doctor first.
We set the price per serving against similar products, cheaper ones with comparable ingredients included.
No numeric score is given. Each product carries a short “best for” label, and each product type has a top pick whose limits we spell out.
Our reviews fall into three health categories. Click one to see its full list, with top picks at the start, followed by detailed reviews and buying guidance.
This group holds sexual health and testosterone-support supplements, HGH-support formulas, topicals and volume products. It has 35 products, and we checked each one's formula, published evidence and guarantee terms.
Libido support, skin creams, bladder support and body contouring make up this group of 10 products. We checked each against the published evidence and the maker's guarantee terms.
HGH-support formulas, NMN, NMNH, trans-resveratrol, spermidine and quercetin all fall here: 9 products in a field where human evidence is still early and no supplement has been shown to slow aging.
We name one top pick per product type after weighing the formula, the published research, the guarantee terms and the price. Each has limits, spelled out in the full reviews. We cover only brands we have affiliate relationships with. These picks are therefore the best of the products we cover, not of every product on the market.
Below is the top pick for each product type, ordered by our overall assessment. Click through for the full review.
| Product | Best For | Category | Guarantee | Review |
|---|---|---|---|---|
BrainPill Leading Edge Health |
Top pick: focus and memory supplements | 💪 Men's Health | 67 days* | Read Review |
VigRX Plus Leading Edge Health |
Top pick: male sexual-health supplements | 💪 Men's Health | 67 days* | Read Review |
GenuinePurity NMN GenuinePurity (Leading Edge Health) |
Top pick: NMN supplements Heads-up: the $19 first-bottle offer auto-renews at $49 every 30 days until you cancel. |
⏳ Anti-Aging | 97 days* | Read Review |
Semenax Leading Edge Health |
Top pick: semen-volume supplements | 💪 Men's Health | 67 days* | Read Review |
Testosil Leading Edge Health |
Top pick: testosterone-support formulas | 💪 Men's Health | Lifetime* | Read Review |
ProSolution Plus Leading Edge Health |
Top pick: men's staying-power formulas | 💪 Men's Health | 67 days* | Read Review |
Kollagen Intensiv Skinception |
Top pick: anti-aging face creams | 🌸 Women's Health | 67 days* | Read Review |
Confitrol24 Leading Edge Health |
Top pick: bladder-support supplements | 🌸 Women's Health | 67 days* | Read Review |
GenF20 Plus Leading Edge Health |
Top pick: HGH-releaser supplements (weak evidence) | ⏳ Anti-Aging | 67 days* | Read Review |
HerSolution Leading Edge Health |
Top pick: women's libido supplements | 🌸 Women's Health | 67 days* | Read Review |
*Guarantees come with conditions (deadlines, returns, shipping), so check each review. We don't publish numeric scores. See how we review →
Head-to-head comparisons and category guides, built on the same checks we use for our reviews.
Guarantees tend to come with deadlines and conditions. Our guide shows what they actually cover.
For each health category, these guides explain what to look for, what to steer clear of and how to match a supplement to your goal.
Quality varies a lot in the men's health supplement market, and exaggerated claims are common. Before you buy, you need to be able to tell products backed by evidence from those driven by marketing.
Start by checking whether the active ingredients are there at doses that matter clinically. Plenty of products list popular ingredients such as Ashwagandha or Fenugreek but at doses far below those used in published studies. The label should state exact ingredient amounts. Treat with caution any product that hides behind “proprietary blends” with no disclosed doses.
Products for women address many concerns, among them libido, skin, bladder support and body contouring. Few have been tested as finished products and many keep their doses private, so check what the evidence actually covers.
Phytoestrogens, plant compounds with weak estrogen-like effects (those in hops, for example), are worth looking for in hormonal-health formulas. Studies are mixed on whether they ease perimenopausal symptoms. A woman with a hormone-sensitive condition should consult her doctor first.
Longevity supplements belong to a young field. NMN has produced small, short human trials that show it raising blood NAD+, while human trials of resveratrol show small and inconsistent effects. Research on spermidine in people is limited. Not one human study shows that any of these slows aging.
With evidence this early, the sensible questions are what's in the bottle and what it costs. Seek out a disclosed dose per serving, the form of the compound (for example, trans-resveratrol) and, if possible, a recent certificate of analysis from an independent lab.
Answers on how we review supplements, how to use this site and what to expect from the products we cover.
Our editorial team does its own research from the product label, the manufacturer's pages and published studies. The brands we review pay us commissions, and we say so on every page. Our aim is to describe each product accurately, limits included, and every product gets the same checks.
No prescription is needed for any of them. Dietary supplements make up most of what we review, with a few cosmetics, an OTC drug (a benzocaine spray), a fragrance and a device. Still, we strongly advise checking with your doctor or healthcare provider before starting any supplement program, especially if you have a medical condition, take prescription medication, are pregnant or are breastfeeding.
Numeric scores aren't part of our approach. We read the label for the formula and doses, search for published trials of the product and its ingredients, read the guarantee terms, note safety cautions and compare the price. After that, a short “best for” label goes on each product, and a top pick is chosen for each product type. Treat a top pick as the best option we found for that need; it is not a promise that it works.
Most of the products we feature come with a manufacturer money-back guarantee, though length and conditions differ. The manufacturer, not Trusted Health Reviews, sets the terms. Each review page shows the specific guarantee length. A refund claim goes to the manufacturer directly; Trusted Health Reviews can't process it. Guarantees apply only to purchases made on the official manufacturer website.
When readers buy through links on this site, Trusted Health Reviews earns affiliate commissions, which manufacturers pay. As far as we know, using our link costs the same as going to the site directly. Since the brands we review pay us, we say where the evidence is weak, which guarantee conditions apply and when a cheaper option may do the same job.
Our aim is to recheck each review at least once a year. A review is also updated when we find new published studies on the product or its key ingredients, when the formula or price changes, when guarantee terms change, or when regulatory guidance changes. Every review page shows its last-updated date, so you can check how current it is.
Botanical extracts, amino acids, vitamins and minerals go into most of the products reviewed on Trusted Health Reviews. Still, natural ingredients can cause side effects and interact with medicines, and few finished products have been studied for long-term use. Before you start any supplement, especially for the long term, we recommend consulting your doctor. Cautions for each product are listed on its review page.
In some cases, yes. A few men's health products, notably the HGH-releaser supplements GenF20 Plus and GenFX, are explicitly formulated for both men and women. Others contain ingredients aimed at male physiology (such as testosterone support compounds) and aren't suitable for women. A review notes when a product suits women. If you're unsure, ask your healthcare provider.
The supplement market is huge, and many products offer little proven benefit. These are the main things to check before you buy.
What matters most is how a product's ingredient doses compare with the doses used in published clinical research. Many brands list fashionable ingredients — Ashwagandha, Berberine, NMN, Resveratrol — at a fraction of the amounts used in clinical studies. Take a supplement with 50mg of Ashwagandha when the published research used 600mg: it is unlikely to produce the results that research suggests are possible.
At Trusted Health Reviews we check more than whether an ingredient is in a formula. We check that it's there at a clinically relevant dose. This is among the most important steps in our review process — and the reason our top picks sometimes differ from popularity rankings.
Under US law, supplement makers must meet cGMP (Current Good Manufacturing Practice) rules on identity testing, contamination controls and label accuracy. That isn't the same as a certification or FDA approval, and the FDA does not approve supplements before they are sold. Many makers say they follow cGMP. Since we can't inspect facilities ourselves, we report only what the maker states.
Lower financial risk is what a money-back guarantee gives you. It does not show that a product works. So read the terms before buying. In most of the guarantees we checked, returned containers have to arrive by a strict deadline (often 67 days from delivery). Some refund only unopened bottles plus one or two opened ones, and refunds of shipping are rare. The main ones are summed up in the “Money-Back Guarantees, Explained” section further down.
Men's Sexual Health Supplements: Few supplement types draw more searches in men's health than products like VigRX Plus, Semenax and ProSolution Plus, yet the evidence behind them varies a great deal. One small published placebo-controlled trial tested VigRX Plus itself (its funding isn't stated). Semenax has one trial too, funded and co-written by its maker. Many rivals have no product trial at all. In total, 35 products appear in our men's health reviews.
Testosterone Support Supplements: Three formulas here disclose all their doses: Testosil, which has 300 mg KSM-66 ashwagandha per serving along with D-aspartic acid and other ingredients; TestRX, with D-aspartic acid, fenugreek, zinc and magnesium; and Testodren, with 500 mg Furosap fenugreek extract. As finished products, though, none has been tested, and some of the doses sit below or outside what research supports. Men who are deficient in zinc and vitamin D are the ones who mainly benefit from them.
Anti-Aging & Longevity Supplements: Shelves now stock NMN (nicotinamide mononucleotide), trans-resveratrol, spermidine and quercetin supplements in volume. GenuinePurity is the range we cover; it sells all four, and several come in liposomal versions. No published trial has tested any GenuinePurity product. GenF20 Plus does have one published trial of the product, though its main result, the IGF-1 change versus placebo, was not statistically significant. A later subgroup analysis is where the advertised rise comes from.
Women's Health Products: Our best-known women's libido products are HerSolution, Provestra and Vigorelle. All three keep ingredient amounts undisclosed, and not one has a published trial of the product. Kollagen Intensiv, from the Skinception range, is a topical face cream rather than a supplement. No test of Confitrol24 itself exists; its Urox blend does have one published placebo-controlled trial, which the company that patents Urox funded.
These are the supplements our readers look up most. Each has a full review of ingredients, published evidence, guarantee terms and an editorial verdict.
The key ingredients that recur across the products we review, with plain notes on what the evidence does and doesn't show.
Ashwagandha (Withania somnifera) extract from the root only, usually studied at 300–600 mg a day, with small trials in men on stress, cortisol and testosterone. In one 8-week trial of young men, 600 mg a day produced a bigger testosterone rise than placebo, though end-of-study levels didn't differ significantly. Used in: Testosil (300 mg per serving). CortiSync uses a different extract, Sensoril (300 mg).
NAD+ precursor. Human trials on it have been small and short (roughly 10–110 people, 250–1,250 mg a day), and they show that blood NAD+ goes up. Results for health outcomes are mixed, and NMN makers paid for several of the trials. Nothing in human research shows it slows aging. Used in: GenuinePurity NMN, GenuinePurity Longevity Plus. A related compound, NMNH, goes into GenuinePurity NMN-H, and it has no peer-reviewed human trial yet.
Most research uses this form of resveratrol. Some animal studies looked promising. Human trials, however, show small, inconsistent effects, the body breaks oral resveratrol down quickly, and nobody has proven direct sirtuin activation in people. Used in: GenuinePurity Trans-Resveratrol (500 mg), GenuinePurity Longevity Plus (100 mg).
A branded black pepper extract included to help absorption. The supplier funded its absorption studies, and they tested other nutrients rather than the formulas it appears in. Piperine can also change how the body processes some prescription drugs, so ask a pharmacist if you take medicines. Found in: VigRX Plus, DIM3X, CalmLean.
Your body turns both of these into nitric oxide, which helps blood vessels relax. Most human studies used gram-level amounts, and many blends contain far less. Used in: VigRX Nitric Oxide (doses not disclosed), GenF20 Plus (130 mg L-arginine per serving), HyperGH 14x (520 mg L-arginine a day).
Digesting cruciferous vegetables forms this compound. Human studies, mostly in women, show it shifting estrogen metabolism at about 100–300 mg a day. We found no human trial showing that it raises testosterone or improves symptoms in men. Used in: DIM3X (200 mg).
A peptide used in skin creams, intended to prompt the skin to make more collagen. The ingredient supplier and the brand, not peer-reviewed trials, are the source of its wrinkle data, and the amount in the cream isn't disclosed. Found in: Kollagen Intensiv (a topical cream, not a supplement).
Crateva nurvala, horsetail (Equisetum arvense) and Lindera aggregata make up this blend. A single published placebo-controlled trial (150 adults, 8 weeks) found fewer bathroom trips and less urgency than with placebo. It was funded by the company that patents Urox, and nobody has repeated it. Used in: Confitrol24 (amount per capsule not disclosed).
How we hold to our standards
Supplement studies don't all carry equal weight. These are the things we look for when we read the research behind a product.
Neither participants nor researchers know who received the supplement and who received the placebo, and that makes this the most dependable way to test a supplement. Both VigRX Plus and Semenax have one small published trial of this type on the product itself, which is rare in this industry. There are caveats. VigRX Plus's trial doesn't state who funded it. Semenax's trial was funded and co-written by its maker. Neither has been repeated independently.
An ingredient at a much lower dose than the one studied may do little. Studies of KSM-66 ashwagandha used 300–600 mg a day, DIM roughly 100–300 mg a day, and L-arginine usually several grams a day. Whether the label doses match the research amounts is what we check, not simply whether the ingredient appears. We also flag labels that don't disclose doses at all.
Only the part of a compound that reaches the bloodstream can help. Take oral resveratrol, which the body breaks down quickly. To get around problems like this, brands often add absorption aids such as BioPerine or AstraGin, or switch to liposomal capsules. Rarely do they test these with the exact formula, so we regard absorption claims as unproven until a study has tested the product itself.
Branded ingredients (KSM-66, Sensoril, Cognizin, Synapsa, SYN-COLL, Furosap) usually have their own studies and a standardized specification, so they're easier to check. Many of those studies, though, were funded by the ingredient supplier, and a low dose of a branded ingredient is still a low dose.
A legal minimum for US supplement makers, Current Good Manufacturing Practice (cGMP) rules are neither a certification nor an FDA approval. Identity testing, contamination controls and label accuracy fall under them, but the FDA doesn't approve supplements before they are sold. Makers often say they follow cGMP, and since we can't inspect facilities, we report what each maker states. You learn more from an independent lab's certificate of analysis, where there is one.
We don't reduce evidence to a number, but we do rank its kinds:
| Strongest | Placebo-controlled trials of the product itself, preferably independent and repeated |
| Moderate | Several human trials of the main ingredients at the doses found in the formula |
| Weak | Small, uncontrolled or company-run studies, traditional use, or animal and lab data |
| None | No published human evidence at the doses used in the formula |
⚠ A note from our editors: Our reviews cite clinical evidence that concerns the active ingredients and, where any is published, the specific products. One form of an ingredient never stands in for another: we don't assume the same effects follow. Where clinical data is limited, we say so outright. Trusted Health Reviews does not make medical claims, and all content is for informational purposes only. *These statements have not been evaluated by the Food and Drug Administration.
Below are our top picks for each category, along with the strongest alternatives where a category has fewer than five top picks. A short label shows what each pick is best for. All picks come from brands that pay us commissions.
The order reflects our overall assessment of formula, evidence, guarantee terms, safety and price. We don't publish numeric scores. Click a product to read its full review.
Nearly all the money-back guarantees on products we review carry conditions, and the terms differ a lot between them. Here is what the main ones cover, according to the manufacturers' own sites in October 2026 (where we could only find terms elsewhere, we say so).
Empty containers must reach the seller within 67 days of delivery. Shipping isn't refunded, and there is one refund per customer.
Testosil advertises its guarantee as lifetime. The refund covers unopened bottles plus one opened bottle, and it doesn't include shipping. Confirm the terms with Testosil before you buy.
Semenax: empty containers need to arrive within 67 days of delivery, with no shipping refund and one refund per customer. Terms of 67 days for HyperGH 14x appear in a company press release; we couldn't confirm them on its site.
Return within 97 days of delivery. Up to two opened bottles are covered, along with any unopened ones; shipping isn't refunded and each customer is limited to one order. GenuinePurity NMN: Heads-up: the $19 first-bottle offer auto-renews at $49 every 30 days until you cancel.
⚠ Guarantee terms: The individual manufacturers set and honour money-back guarantees, not Trusted Health Reviews. To claim a refund, contact the manufacturer directly within the stated window (in most of the terms we checked, it counts from delivery). Most terms don't say they cover purchases from other sellers, so the official site is the safest place to buy. Keep your order confirmation email as proof of purchase. Each manufacturer's website details its own terms and conditions.
These are terms common in supplement science and in our reviews, explained plainly so you can follow the evidence in any review.
Combinations of supplements are rarely tested, though some of those reviewed on Trusted Health Reviews can be taken together. No trial has shown that NMN plus resveratrol works better than either alone, for instance. To avoid going over safe upper limits, look for ingredient overlap, in Zinc, Vitamin D and fat-soluble vitamins especially. Prescription medication users should ask their doctor before adding any supplement or combination.
Ingredient form (patented vs. generic), dose levels compared with clinical research amounts, manufacturing certification standards, spending on third-party testing and brand overhead all push prices up or down. Expect a branded extract at a full research dose to cost more than a generic extract at a fraction of that dose. Price by itself is a poor guide to quality, though. Some premium products have no more evidence than cheaper ones, so weigh the label and the research instead of the price alone.
Marketplace reviews from third parties deserve caution. Counterfeits of many of the supplements we review are sold on Amazon, and a counterfeit produces different results (or none), which leads to misleading negative reviews. Incentivised and fake reviews are widespread there as well. Read user reviews anywhere as one signal among many, and give more weight to published research and clear ingredient labels.
Keep most oral capsules and tablets in a cool, dry place out of direct sunlight and humidity. A bathroom is a poor choice because of the moisture. NMN and other longevity compounds are sensitive to heat and moisture, and some manufacturers recommend refrigeration after opening, so look at each manufacturer's guidance for the product. Follow the storage instructions on the label.
Medicines and dietary supplements are regulated differently in the US. Before the FDA grants marketing approval, a medicine (pharmaceutical) has to prove its safety and efficacy in clinical trials. A dietary supplement needs no approval before it goes on sale and is regulated once it's on the market, and its maker may not legally claim that it can diagnose, treat, cure or prevent any disease. Of the products we review, most are dietary supplements; some are cosmetics, an OTC drug (a benzocaine spray), a fragrance or a device. For this reason our content is explicitly for informational purposes only, not a replacement for medical advice.
“Clinically studied ingredients” tells you only that the separate active compounds in a formula have appeared in published human clinical research. The finished product, meaning the actual supplement on the shelf, may never have been put through a clinical trial, and that is a far higher bar. Whenever we say a product has a published clinical study, the study is on that exact product. This matters because VigRX Plus, Semenax and GenF20 Plus are among the few we review with one small published study of the product itself (each review describes its limits), whereas most rivals can point only to evidence on ingredients.